The value of C-reactive protein in pre-clinical and clinical research is well established, and our species-specific CRP kits have a proven track record in important areas such as autoimmune and cardiovascular diseases, nutrition and toxicology research and a growing field of new applications. In addition, in mice, SAP is known to play an important role in conditions mediated by the inflammatory process.(Mortensen, R.F., Beisel, K., Zeleznik, N.J., and Le, P.T. Strain dependence of serum amyloid P-component levels and response to inflammation. Journal of Immunology. 1983; 130(2):885-889.) These specialized kits are also adapted for investigational work involving urine and other body fluids and tissues as well as culture supernatants. Please ask for our assistance in developing special protocols (modification of existing kits or novel assays) that can expand your research goals and enable you to discover additional dimensions to your findings. Package inserts, product brochure, and published literature are always available by request: email@example.com.
C-Reactive Protein, Canine.................3.6 - 40 ng/mL
C-Reactive Protein, Rat.....................2.5 - 133 ng/mL
C-Reactive Protein, Human.................0.12 - 10 ng/mL
C-Reactive Protein, Mouse..................1.56 - 25 ng/mL
C-Reactive Protein, Primate................0.12 - 10 ng/mL
C-Reactive Protein, Rabbit..................1.56 - 25 ng/mL
Serum Amyloid P, Mouse....................5.12 - 200 ng/mL
View our C-Reactive Protein Kits product page
View our product reviews on Rat CRP ELISA
View our product reviews Dog CRP ELISA
RECENT CITATIONS WITH HELICA BIOSYSTEMS CRP KITS
Jayachandran, M., et.al., Effect of geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamsters. Molecular and Cellular Biochemistry. 2015;398(1-2):39-53
Ferreira, Thaís da Silva, et.al., Vitamin D deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women. Nurtrición Hospitalaria .2015; 31 (4): 1491-1498.
Argente, María-José, et.al., Relationship between cortisol and acute phase protein concentrations in female rabbits. The Veterinary Journal.2014;202(1):172-175
Li, Qiling, et.al., A promoter that drives gene expression preferentially in male transgenic rats. Transgenic Research. 2014;23(2):341-349
Vetvicka,V. and Vetvickova,J. , Immune-enhancing effects of Maitake (Grifola frondosa) and Shitake (Lentinula edodes) extracts. Annals of Translational Medicine.2014;2 (2):14
Durbin, Stephanie M., et.al., Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats. Journal of Bone and Mineral Metabolism. 2014;32 (1):38-47
Mizutani, K., et.al., Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. Journal of Dental Research. 2014;27(1):24-29
Arija, V., et.al, Excess body iron and the risk of type 2 diabetes mellitus: a nested case-control in the PREDIMED (PREvention with MEDiterranean Diet) study. British Journal of Nutrition. 2014;11:1896-1904
Kazumasa, M. , et.al., Increased TLR2 and TLR4 Expression in Peripheral Neutrophils Isolated from Kawasaki Disease. Pediatric Allergy, Immunology, and Pulmonology . 2014;27(1):24-29
Barrett, A., et.al., α1-antitrypsin and C-reactive protein levels in tear fluid after continuous contact lens wear. Clinical and Experimental Optometry. 2014;97(1):66-71
Matthews, Shawna B., et al. Excess weight gain accelerates 1-methyl-1-nitrosourea-induced mammary carcinogenesis in a rat model of premenopausal breast cancer. Cancer Prevention Research. 2014: canprevres-0297
Barrett, Aaron et al. α1-antitrypsin and C-reactive protein levels in tear fluid after continuous contact lens wear. Clinical and Experimental Optometry. 2014;97(1):66-71
Sasaki, Tomohiko, et al. C-reactive protein inhibits lymphangiogenesis and resultant lymph node metastasis of squamous cell carcinoma in mice. Surgery. 154.5 2013: 1087-1092
Ye, Changchang, et al. The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth. Archives of Gynecology and Obstetrics. 2013;288(1): 65-72
Li, Qiling, et al. A promoter that drives gene expression preferentially in male transgenic rats. Transgenic Research. 2013: 1-9
Gómez-Zorita, Saioa, et al. Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats. Nutrition. 2013; 29: 1374-1380
Clancy, Kathryn BH, Angela R. Baerwald, and Roger A. Pierson. Systemic Inflammation Is Associated with Ovarian Follicular Dynamics during the Human Menstrual Cycle. PloS one 8. 2013:no. 5 e64807
Bae, Yun-Jung, et al. Evaluation of Adiposity-Related Biomarkers as Metabolic Syndrome Indicators. Clinical Nutrition Research. 2013;2(2):91-99
da Silva Ferreira, Thaís, Márcia Regina Simas Gonçalves Torres, and Antonio Felipe Sanjuliani. Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women. British Journal of Nutrition . 2013;110 (06): 1079-1088
Clancy, Kathryn BH, et al. Relationships between biomarkers of inflammation, ovarian steroids, and age at menarche in a rural Polish sample. American Journal of Human Biology. 2013; 25:389-398
Arafa, Nadia MS, et al. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model Toxicology and Industrial Health. 2013; 9:187-201
Parada, Belmiro, et al. Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer. BioMed Research International. 2013
Juanola-Falgarona, Martí, et al. Association between Serum Ferritin and Osteocalcin as a Potential Mechanism Explaining the Iron-Induced Insulin Resistance. PloS One. 2013: 8.10, e76433
Fahmy, Nader, et al. Ochratoxin A is not detectable in renal and testicular tumours. Canadian Urological Association Journal. 2014: 8.1-2 40-6
Jiang, W. Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas. Carcinogenesis. 2013;34: 378-387
Srinivasan, S. and L.Pari, Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats. Journal of Functional Foods. 2013; 5: 484-492
Chongwatpol, P., Body Fat Distribution, Dietary and Serum Anti-oxidants, and Insulin Resistance of Older Oklahoma Women With and Without Metabolic Syndrome. Oklahoma State University Thesis Archive. 2012.
Cooper, J., Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults. Metabolism. 2012; 61:1589-1597
Durbin, S., Resveratrol supplementation influences bone properties in the tibia of hindlimb-suspended mature Fisher 344 × Brown Norway male rats. Applied Physiology, Nutrition, and Metabolism. 2012;37: 1179-1188.
García M.L., Effect of Divergent Selection for Residual Variance of Litter Size on Health Status and Welfare. Proceedings 10th World Rabbit Congress. 2012; 103- 106
Ginsberg, Y., et.al.,Maternal lipopolysaccharide alters the newborn oxidative stress and C-reactive protein levels in response to an inflammatory stress. Journal of Developmental Origins of Health and Disease. 2012;3: 358-363
Kim, H.J., A Six-Month Supplementation of Mulberry, Korean Red Ginseng, and Banaba Decreases Biomarkers of Systemic Low-Grade Inflammation in Subjects with Impaired Glucose Tolerance and Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine. 2012; Article ID 735191, 10.1155
Ling,P-R, Malkan, A, H.D.Le, M. Puder, B. R.Bistrian .Arachidonic acid and docosahexaenoic acid supplemented to an essential fatty acid-deficient diet alters the response to endotoxin in rats. Metabolism - Clinical and Experimental. 2012; 61:395-406.
Ling,P-R, et.al. Effects of glucose or fat calories in total parenteral nutrition on fat metabolism and systemic inflammation in rats. an essential fatty acid-deficient diet alters the response to endotoxin in rats. Metabolism - Clinical and Experimental. 2012;60:195-205
Ling,P-R, et.al. Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. Metabolism. 2012; 61:1443 - 1451.
Mima, A., et. al., Retinal Not Systemic Oxidative and Inflammatory Stress Correlated with VEGF Expression in Rodent Models of Insulin Resistance and Diabetes. Invest. Ophthalmol. Vis. Sci.. 2012; 53: 8424-8432
M. Inoue, Role of the spleen in the development of steatohepatitis in high-fat-diet-induced obese rats. Exp Biol Med. 2012; 237: 461-470.
Vrana, N.E., et.al. Modification of macroporous titanium tracheal implants with biodegradable structures: Tracking in vivo integration for determination of optimal in situ epithelialization conditions. Biotechnology and Bioengineering. 2012;109: 2134-2146
Zongjian Zhu, et.al., Effects of Energy Restriction and Wheel
Running on Mammary Carcinogenesis and Host Systemic Factors in a Rat Model. Cancer Prev Res.. 2012;5: 414 - 422
Arafa, N., et al. The effectiveness of Echinacea extract or
composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Toxicology & Industrial Health. 2011; 12 - 15.
Marwa A Ahmed and Gehan M ELosaily. Role of Oxytocin in deceleration of early atherosclerotic inflammatory processes in adult male rats. Int J Clin Exp Med.. 2011; 4:169-178.
Morshed, M.A., J. Alam, M. Das, A. Haque, L. Ali, B. Rokeya.
Antidiabetic and anti-inflammatory activity of Urtica dioica leaves on STZ induced type 1 diabetic model rats. International Journal of Pharmaceutical Sciences and Research. 2011; 2:1182-1187.
Parada, B., et.al. Inhibition of Bladder Tumour Growth By Sirolimus In An Experimental Carcinogenesis Model. BJUI. 2011; 107:125-143.
Patel, H., et.al. Effects of Diesel Particulate Matters On Inflammatory Responses In Static And Dynamic Culture of Human Alveolar Epithelial Cell. Toxicology Letters. 2011; 200:124-131.
Teixeira de Lemos, et.al. Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and
Oxidative Stress Status in an Animal Model of
Type 2 Diabetes Mellitus. Mediators of Inflammation. 2011; 253061:1-11
Yuan-Horng Yan, et.al Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation. Inhalation Toxicology. 2011: 23, 507-519.
Zongjian Zhu, Weiqin Jiang, John N. McGinley, Bogdan Prokopczyk, John P. Richie, Jr., Karam El-Bayoumy, Andrea Manni, and Henry J. Thompson. Mammary Gland Density Predicts The Cancer Inhibitory Activity of The N-3 To N-6 Ratio of Dietary Fat. Cancer Prevention Research. 2011; 4:2
Ann Pellizzaro, Rita M. Heuertz. C-Reactive Protein Levels Are Elevated In Asthma And Asthma-like Conditions. Clinical Laboratory Science. 2010; 23: 223-227
Brown, D.E., et al. Relation Between C-reactive Protein Levels And Body Composition In A Multiethnic Sample Of School Children In Hawaii. American Journal of Human Biology. 2010; 22:675-679.
Dumas, J-F. N-3 PUFA-Enriched Diet Delays the Occurrence of Cancer Cachexia in Rat With Peritoneal Carcinosis. Nutrition And Cancer. 2010; 62:343-350.
Fabrini, E., et.al. Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity And Cardiovascular Risk Factors In Obese Adults. Gastroenterology AGA Institute. 2010; 139:448-455.
Ferreira, L. Effects Of Sitagliptin Treatment On Dysmetabolism, Inflammation And Oxidative Stress In An Animal Model Of Type 2 Diabetes (ZDF Rat). Mediators of Inflammation. 2010
Gosens, I., et. al. Impact of Agglomeration State of Nano- And Submicron Sized Gold Particles On Pulmonary Inflammation. Particle And Fibre Toxicology. 2010; 7:37:1-11.
Ivo Laidmäe, et.al. Characterization of The Biological Effect of Fish Fibrin Glue In Experiments On Rats: Immunological and Coagulation Studies. Journal of Biomedical Materials Research Part A. 2010; 93A:29-36
Khaled Abou El Fadl, MD, et. al. Periodontitis And Cardiovascular Disease: Floss And Reduce A Potential Risk Factor For CVD. Angiology. 2010; 61
Lin, Kai-Chun, et al. Biogenic Nanoporous Silica-based Sensor For Enhanced Electrochemical Detection Of Cardiovascular Biomarkers Proteins. Biosensors And Bioelectronics. 2010; 25:2336-2342
Santos, Ivan Carlos, et.al. Angiostatic Activity of Human Plasminogen Fragments Is Highly Dependent On Glycosylation. Cancer Science. 2010; 101:453-459.
Sereno, Jose, et. al. Preventive but Not Curative Efficacy of Celecoxib On Bladder Carcinogenesis In A Rat Model. Mediators of Inflammation. 2010; Article 380937:1-11
Sloan, Daniela. Effects of Ozone On Blood Components. University of South Florida. Diss. 1772.
Piloto, N. Erythropoietin Promotes Deleterious Cardiovascular Effects And Mortality Risk In A Rat Model Of Chronic Sports Doping. Cardiovascular Toxicology. 2009; 9:201-210
Nagatomo, F. et.al., Effects Of Exposure To Hyperbaric Oxygen On Oxidative Stress in Rats With Type II Collagen-Induced Arthritis. Clinical And Experimental Medicine. 2009; 10:7-13
Terra X., et.al. Grape-seed Procyanidins Prevent Low-grade Inflammation By modulating Cytokine Expression In Rats Fed A High-fat Diet. The Journal Of Nutritional Biochemistry. 2009; 20: 210-218
Linz Wolfgang, Wohlfart Paulus, Baader Manuel, et.al. The Peroxisome Proliferator-activated Receptor- (PPAR- ) Agonist, AVE8134, Attenuates The Progression Of Heart Failure And Increases Survival In Rats. Acta Pharmacologica Sinica. 2009; 30: 935-946
Garrido P., et.al. Characterization of a Rat Model of Moderate Chronic Renal Failure: Focus on Hematological, Biochemical, and Cardio-Renal Profiles. The Open Drug Discovery Journal. 2009; 31:833-842
Ling, S. and F. Jamali. The Effect of Infliximab on Hepatic Cytochrome P450 and Pharmacokinetics of Verapamil in Rats with Pre-Adjuvant Arthritis: A Drug-Disease and Drug-Drug Interaction. Nordic Pharmacological Society. 2009; 105:24-29
Stokes Karen Y., Dugas Tammy R., Tang Yaoping, et.al. Dietary Nitrite Prevents Hypercholesterolemic Microvascular Inflammation and Reverses Endothelial Dysfunction. AJP - Heart And Circulatory Physiology. 2009; 296:H1281-H1288
MagnÈa JoÎlle, Mariottia FranÁois, Fischera Romy, et.al. Early Postprandial Low-grade inflammation After High-fat Meal In Healthy Rats: Possible Involvement of Visceral Adipose Tissue. The Journal of Nutritional Biochemistry. 2009
Desai Mina, Gayle Dave A., Casillas Ederlen, et.al. Early Undernutrition Attenuates the Inflammatory Response In Adult Rat Offspring. Journal of Maternal-Fetal and Neonatal Medicine. 2009; 22(7):571-575
Driscoll DF, Ling PR, Andersson C, Bistrian BR., et.al. Hepatic Indicators of Oxidative Stress and Tissue Damage Accompanied By Systemic Inflammation in Rats Following a 24-hour Infusion of an Unstable Lipid Emulsion Admixture. JPEN J Parenter Enteral Nutr. 2009; 33(3):327-335
Ortiz R., et. al. Aldosterone Receptor Antagonism Reduces Urinary C-Reactive Protein Excretion In Angiotensin II-Infused. Hypertensive Rats. Journal of the American Society of Hypertension. 2009; 3:184-191
Magee, Thomas R., et. al. Down-regulation of Transcription Factor Peroxisome Proliferator-activated Receptor In Programmed Hepatic Lipid Dysregulation and Inflammation In Intrauterine Growth-restricted Offspring. American Journal of Obstetrics and Gynecology. 2008; 271:271e1-271e5
Veiga, A. P. M., et. al. Association of Canine Obesity With Reduced Serum Levels of C-reactive Protein. Journal of Veterinary Diagnostic Investigation. 2008; 20:224-228
Clements John D., Jamali Fakhreddin, Pravastatin Reverses The Down-regulating Effect of Inflammation on β-Adrenergic Receptors: A disease-drug Interaction Between Inflammation, Pravastatin, and Propranolol. Vascular Pharmacology. 2007; 46(1):52-59
Teixiera de Lemos. E. et. al. Exercise Training Is Adiponectin in ZDF (type 2) Diabetic Rats. Med. Sci. Monit. 2007; 13: 168-174
Cai, X., et al. The comparative study of Sprague-Dawley and Lewis rats in adjuvant-induced arthritis Naunyn-Schmiedeberg's archives of pharmacology. 2006; 373.2 :140-147
Chen, K. et. al. Induction of Leptin Resistance Through Direct Interaction Of C-reactive Protein With Leptin. Nature Medicine. 2006; 12:425 - 432 (Human CRP)
Cho W. C., et. al. Altered Expression of Serum Protein In Ginsenoside Re-treated Diabetic Rats Detected By SELDI-TOF MS. Journal of Ethnopharmacology. 2006; 108(2):272-279
Cho, William C., et al. Differential expression of proteins in kidney, eye, aorta, and serum of diabetic and non‐diabetic rats. Journal of cellular biochemistry. 2006; 99.1 256-268
Kalani, R., et.al. Effects Of Caloric Restriction And Exercise On Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006; 61A:3:211-217
Lei Yu-Chen, Hwang Jing-Shiang, Chana Chang-Chuan, et.al.
Enhanced Oxidative Stress and Endothelial Dysfunction In Streptozotocin-diabetic Rats Exposed To Fine Particles. Environmental Research. 2005; 99(3):335-343
Buduneli, E. et. al. Systemic Low-Dose Doxycycline and Alendronate Administration and Serum Interleukin-
1Beta, Osteocalcin, and C-Reactive Protein Levels in Rats. Journal of Periodontology. 2005;76:1927-1933
Ling, S. and F. Jamali. Effect of Early Phase Adjuvant Arthritis on Hepatic P450 Enzymes and Pharmacokinetics of Verapamil: An Alternative Approach to the Use of An Animal Model for Inflammation for Pharmacokinetic Studies. Drug Metabolism and Disposition. 2005; 33:579-586
Shagdarsuren, E. et al. Complement Activation in Angiotensin II-Induced Organ Damage. Circ Res. 2005; 97:716-724